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Assessment of the Psoriatic Transcriptome in a Large Sample: Additional Regulated Genes
 

Summary: Assessment of the Psoriatic Transcriptome in
a Large Sample: Additional Regulated Genes
and Comparisons with In Vitro Models
Johann E. Gudjonsson1,4
, Jun Ding2,4
, Andrew Johnston1
, Trilokraj Tejasvi1
, Andrew M. Guzman1
,
Rajan P. Nair1
, John J. Voorhees1
, Goncalo R. Abecasis2
and James T. Elder1,3
To further elucidate molecular alterations in psoriasis, we performed a gene expression study of 58 paired
lesional and uninvolved psoriatic and 64 control skin samples. Comparison of involved psoriatic (PP) and
normal (NN) skin identified 1,326 differentially regulated transcripts encoding 918 unique genes (549 up- and
369 downregulated), of which over 600 are to our knowledge previously unreported, including S100A7A, THRSP,
and ELOVL3. Strongly upregulated genes included SERPINB4, PI3, DEFB4, and several S100-family members.
Strongly downregulated genes included Wnt-inhibitory factor-1 (WIF1), b-cellulin (BTC), and CCL27. Enriched
gene ontology categories included immune response, defense response, and keratinocyte differentiation.

  

Source: Abecasis, Goncalo - Department of Biostatistics, University of Michigan

 

Collections: Biology and Medicine; Mathematics