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Cell Stem Cell Molecular Analysis of Stem Cells and Their

Summary: Cell Stem Cell
Molecular Analysis of Stem Cells and Their
Descendants during Cell Turnover and Regeneration
in the Planarian Schmidtea mediterranea
George T. Eisenhoffer,1 Hara Kang,1 and Alejandro Sa´ nchez Alvarado1,*
1Department of Neurobiology and Anatomy, Howard Hughes Medical Institute, University of Utah School of Medicine, 401 MREB,
20N 1900E, Salt Lake City, UT 84132, USA
*Correspondence: sanchez@neuro.utah.edu
DOI 10.1016/j.stem.2008.07.002
In adult planarians, the replacement of cells lost to
physiological turnover or injury is sustained by the
proliferation and differentiation of stem cells known
as neoblasts. Neoblast lineage relationships and
the molecular changes that take place during differ-
entiation into the appropriate cell types are poorly
understood. Here we report the identification and
characterization of a cohort of genes specifically ex-
pressed in neoblasts and their descendants. We find


Source: Alvarado, Alejandro Sánchez - Department of Neurobiology and Anatomy, University of Utah


Collections: Biology and Medicine