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Equalization of Synaptic Efficacy by Activity-and Timing-Dependent Synaptic Plasticity

Summary: Equalization of Synaptic Efficacy by Activity- and Timing-Dependent
Synaptic Plasticity
Clifton C. Rumsey and L. F. Abbott
Volen Center for Complex Systems and Department of Biology, Brandeis University, Waltham, Massachusetts 02454-9110
Submitted 15 September 2003; accepted in final form 11 December 2003
Rumsey, Clifton C. and L. F. Abbott. Equalization of synaptic
efficacy by activity- and timing-dependent synaptic plasticity. J Neu-
rophysiol 91: 22732280, 2004. First published December 17, 2003;
10.1152/jn.00900.2003. In many neurons, synapses increase in
strength as a function of distance from the soma in a manner that
appears to compensate for dendritic attenuation. This phenomenon
requires a cooperative interaction between local factors that control
synaptic strength, such as receptor density and vesicle release prob-
ability, and global factors that affect synaptic efficacy, such as atten-
uation and boosting by active membrane conductances. Anti-spike-
timing-dependent plasticity, in combination with nonassociative syn-
aptic potentiation, can accomplish this feat even though it acts locally
and independently at individual synapses. Analytic computations and
computer simulations show that this combination of synaptic plastic-
ity mechanisms equalizes the efficacy of synapses over an extended


Source: Abbott, Laurence - Center for Neurobiology and Behavior & Department of Physiology and Cellular Biophysics, Columbia University


Collections: Biology and Medicine