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A Model Neuron with Activity-Dependent Conductances Regulated by Multiple Calcium Sensors
 

Summary: A Model Neuron with Activity-Dependent Conductances Regulated
by Multiple Calcium Sensors
Zheng Liu, Jorge Golowasch, Eve Marder, and L. F. Abbott
Volen Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02254
Membrane channels are subject to a wide variety of regulatory
mechanisms that can be affected by activity. We present a
model of a stomatogastric ganglion (STG) neuron in which
several Ca2
-dependent pathways are used to regulate the
maximal conductances of membrane currents in an activity-
dependent manner. Unlike previous models of this type, the
regulation and modification of maximal conductances by elec-
trical activity is unconstrained. The model has seven voltage-
dependent membrane currents and uses three Ca2
sensors
acting on different time scales. Starting from random initial
conditions over a given range, the model sets the maximal
conductances for its active membrane currents to values that
produce a predefined target pattern of activity 90% of the
time. In these models, the same pattern of electrical activity can

  

Source: Abbott, Laurence - Center for Neurobiology and Behavior & Department of Physiology and Cellular Biophysics, Columbia University

 

Collections: Biology and Medicine