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Major Dissociation Between Medial and Lateral Entorhinal

Summary: Major Dissociation Between
Medial and Lateral Entorhinal
Input to Dorsal Hippocampus
Eric L. Hargreaves,1,2
Geeta Rao,1
Inah Lee,1
* James J. Knierim1
Hippocampal place cells are a model system of how the brain constructs
cognitive representations and of how these representations support complex
behavior, learning, and memory. There is, however, a lack of detailed knowl-
edge about the properties of hippocampal afferents. We recorded multiple
single units from the hippocampus and the medial and lateral entorhinal areas
of behaving rats. Although many medial entorhinal neurons had highly
specific place fields, lateral entorhinal neurons displayed weak spatial
specificity. This finding demonstrates a fundamental dissociation between
the information conveyed to the hippocampus by its major input streams,
with spatial information represented by the medial and nonspatial in-
formation represented by the lateral entorhinal cortex.
The hippocampus and related structures in the


Source: Andrzejak, Ralph Gregor - Departament de Tecnologia, Universitat Pompeu Fabra
Lee, Inah - Department of Brain and Cognitive Sciences, Seoul National University
Wagner, Anthony - Department of Psychology, Stanford University


Collections: Biology and Medicine; Computer Technologies and Information Sciences