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The Journal of Neuroscience, March 1991, 77(3): 760-769 Serotonin Selectively Attenuates Glutamate-Evoked Activation of
 

Summary: The Journal of Neuroscience, March 1991, 77(3): 760-769
Serotonin Selectively Attenuates Glutamate-Evoked Activation of
Noradrenergic Locus Coeruleus Neurons
Gary Aston-Jones,' Hideo Akaoka,' Paul Charl&y,2 and Guy Chouvet*
`INSERM Unit4 171 and CNRS URA119.5, Centre Hospitalier Lyon Sud, 69310 Pierre Bbnite, France, and `Division of
Behavioral Neurobiology, Department of Mental Health Sciences, Hahnemann University Medical School, Philadelphia,
Pennsylvania 19102
The effect of 5-HT on activity of noradrenergic locus coe-
ruleus (LC) neurons was studied using microiontophoretic
and micropressure drug application in anesthetized rats. 5-HT
had no consistent effect on LC spontaneous discharge, elic-
iting a modest decrease overall. However, 5-HT reliably at-
tenuated responses of LC neurons to excitatory amino acids
(EAAs), one of the major classes of transmitters in afferents
to these neurons. This effect was specific for EAA responses
because it occurred for glutamate and kainate but not for
ACh. In contrast, iontophoretic norepinephrine (NE) selec-
tively attenuated spontaneous activity but not responses
evoked by either glutamate or ACh. The responsiveness of
LC neurons to EAAs as quantified by a response-contrast

  

Source: Aston-Jones, Gary - Department of Neurosciences, Medical University of South Carolina

 

Collections: Biology and Medicine