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Summary: Cell, Vol. 79, 717-727, November 19, 1994, Copyright 0 1994 by Cell Press
Synaptotagmin I: A Major Ca*+ Sensor
for Transmitter Release at a Central Synapse
Martin Geppert,' Yukiko Goda,f'Robert E. Hammer,@
Cai Li,* Thomas W. RosahI; Charles F. Stevens,t
and Thomas C. Siiclhof'l
*Department of Molecular Genetics
*Department of Biochemistry
§Howard Hughes Medical Institute
The University of Texas Southwestern Medical Center
Dallas, Texas 75235
tMolecular Neurobiology Laboratory
and Howard Hughes Medical Institute
The Salk Institute
La Jolla, California 92037
Summary
Mice carrying a mutation in the synaptotagmin I gene
were generated by homologous recombination. Mu-
tant mice are phenotypically normal as heterozygotes,
but die within 48 hrafter birth as homozygotes. Studies
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