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Summary: From flies' eyes to our ears: Mutations in a human
class III myosin cause progressive nonsyndromic
hearing loss DFNB30
Tom Walsh*, Vanessa Walsh*, Sarah Vreugde
, Ronna Hertzano
, Hashem Shahin
, Smadar Haika
, Ming K. Lee*,
Moien Kanaan
, Mary-Claire King*§
, and Karen B. Avraham
*Departments of Medicine and Genome Sciences, University of Washington, Seattle, WA 98195-7720; Department of Human Genetics and
Molecular Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel; and Department of Life Sciences,
Bethlehem University, Bethlehem, Palestinian Authority
Edited by A. James Hudspeth, The Rockefeller University, New York, NY, and approved March 22, 2002 (received for review February 13, 2002)
Normal vision in Drosophila requires NINAC, a class III myosin. Class
III myosins are hybrid motor-signaling molecules, with an N-
terminal kinase domain, highly conserved head and neck domains,
and a class III-specific tail domain. In Drosophila rhabdomeres,
NINAC interacts with actin filaments and with a PDZ scaffolding
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