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BioMed Central Page 1 of 22

Summary: BioMed Central
Page 1 of 22
(page number not for citation purposes)
BMC Bioinformatics
Open AccessMethodology article
Bioinformatics analysis of the early inflammatory response in a rat
thermal injury model
Eric Yang1, Timothy Maguire1, Martin L Yarmush1, Francois Berthiaume2 and
Ioannis P Androulakis*1
Address: 1Biomedical Engineering Department, Rutgers University, Piscataway, NJ, USA and 2Center for Engineering in Medicine/Surgical Services,
Massachusetts General Hospital, Harvard Medical School, and the Shriners Hospitals for Children, Boston, MA, USA
Email: Eric Yang - eyang@eden.rutgers.edu; Timothy Maguire - timjm@eden.rutgers.edu; Martin L Yarmush - kma@soemail.rutgers.edu;
Francois Berthiaume - Francois_Berthiaume@hms.harvard.edu; Ioannis P Androulakis* - yannis@rci.rutgers.edu
* Corresponding author
Background: Thermal injury is among the most severe forms of trauma and its effects are both
local and systemic. Response to thermal injury includes cellular protection mechanisms,
inflammation, hypermetabolism, prolonged catabolism, organ dysfunction and immuno-
suppression. It has been hypothesized that gene expression patterns in the liver will change with
severe burns, thus reflecting the role the liver plays in the response to burn injury. Characterizing


Source: Androulakis, Ioannis (Yannis) - Biomedical Engineering Department & Department of Chemical and Biochemical Engineering, Rutgers University


Collections: Engineering; Biology and Medicine