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Requirement for a conserved Toll interleukin-1 resistance domain protein in the Caenorhabditis
 

Summary: Requirement for a conserved Toll interleukin-1
resistance domain protein in the Caenorhabditis
elegans immune response
Nicole T. Liberati*, Katherine A. Fitzgerald
, Dennis H. Kim*, Rhonda Feinbaum*, Douglas T. Golenbock
,
and Frederick M. Ausubel*
*Department of Genetics, Harvard Medical School, and Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114; and Division
of Infectious Disease and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605
Contributed by Frederick M. Ausubel, December 29, 2003
The p38 mitogen-activated protein kinase pathway regulates in-
nate immune responses in evolutionarily diverse species. We have
previously shown that the Caenorhabditis elegans p38 mitogen-
activated protein kinase, PMK-1, functions in an innate immune
response pathway that mediates resistance to a variety of micro-
bial pathogens. Here, we show that tir-1, a gene encoding a highly
conserved Toll IL-1 resistance (TIR) domain protein, is also required
for C. elegans resistance to microbial pathogens. RNA interference
inactivation of tir-1 resulted in enhanced susceptibility to killing by
pathogens and correspondingly diminished PMK-1 phosphoryla-

  

Source: Ausubel, Frederick M. - Department of Genetics, Harvard University

 

Collections: Biology and Medicine