Summary: -Ketoisocaproate-induced hypersecretion of insulin by islets
from diabetes-susceptible mice
Mary E. Rabaglia,1
Mark P. Gray-Keller,1
Brian L. Frey,2
Michael R. Shortreed,2
Lloyd M. Smith,2
and Alan D. Attie1
Departments of 1
Biochemistry and 2
Chemistry, University of Wisconsin-Madison, Madison, Wisconsin
Submitted 6 December 2004; accepted in final form 28 February 2005
Rabaglia, Mary E., Mark P. Gray-Keller, Brian L. Frey, Michael
R. Shortreed, Lloyd M. Smith, and Alan D. Attie. -Ketoisocaproate-
induced hypersecretion of insulin by islets from diabetes-susceptible
mice. Am J Physiol Endocrinol Metab 289: E218­E224, 2005. First
published March 1, 2005; doi:10.1152/ajpendo.00573.2004.--Most pa-
tients at risk for developing type 2 diabetes are hyperinsulinemic. Hy-
perinsulinemia may be a response to insulin resistance, but another
possible abnormality is insulin hypersecretion. BTBR mice are insulin

Source: Attie, Alan D. - Department of Biochemistry, University of Wisconsin at Madison

Collections: Biology and Medicine