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Site-directed protein recombination as a shortest-path problem
 

Summary: Site-directed protein recombination as a
shortest-path problem
Jeffrey B.Endelman1,2
, Jonathan J.Silberg3
,
Zhen-Gang Wang2,3
and Frances H.Arnold1,2,3
1
Bioengineering Option and 3
Division of Chemistry and Chemical
Engineering, California Institute of Technology, Mail Code 210-41,
Pasadena, CA 91125-4100, USA
2
To whom correspondence should be addressed.
E-mail: endelman@caltech.edu; zgw@cheme.caltech.edu;
frances@cheme.caltech.edu
Protein function can be tuned using laboratory evolution, in
which one rapidly searches through a library of proteins
for the properties of interest. In site-directed recombination,
ncrossovers are chosen in analignment of p parents todefine

  

Source: Arnold, Frances H. - Division of Chemistry and Chemical Engineering, California Institute of Technology

 

Collections: Chemistry; Biology and Medicine