Summary: Obesity and genetics regulate microRNAs in islets, liver,
and adipose of diabetic mice
Enpeng Zhao Æ Mark P. Keller Æ Mary E. Rabaglia Æ Angie T. Oler Æ
Donnie S. Stapleton Æ Kathryn L. Schueler Æ Elias Chaibub Neto Æ
Jee Young Moon Æ Ping Wang Æ I-Ming Wang Æ Pek Yee Lum Æ
Irena Ivanovska Æ Michele Cleary Æ Danielle Greenawalt Æ John Tsang Æ
Youn Jeong Choi Æ Robert Kleinhanz Æ Jin Shang Æ Yun-Ping Zhou Æ
Andrew D. Howard Æ Bei B. Zhang Æ Christina Kendziorski Æ Nancy A. Thornberry Æ
Brian S. Yandell Æ Eric E. Schadt Æ Alan D. Attie
Received: 22 July 2009 / Accepted: 14 August 2009 / Published online: 1 September 2009
Ó Springer Science+Business Media, LLC 2009
Abstract Type 2 diabetes results from severe insulin
resistance coupled with a failure of b cells to compensate
by secreting sufficient insulin. Multiple genetic loci are
involved in the development of diabetes, although the
effect of each gene on diabetes susceptibility is thought to
be small. MicroRNAs (miRNAs) are noncoding 19­22-
nucleotide RNA molecules that potentially regulate the
expression of thousands of genes. To understand the
relationship between miRNA regulation and obesity-

Source: Attie, Alan D. - Department of Biochemistry, University of Wisconsin at Madison
Yandell, Brian S. - Departments of Statistics & Horticulture, University of Wisconsin at Madison

Collections: Biology and Medicine; Mathematics