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Obesity and genetics regulate microRNAs in islets, liver, and adipose of diabetic mice

Summary: Obesity and genetics regulate microRNAs in islets, liver,
and adipose of diabetic mice
Enpeng Zhao Mark P. Keller Mary E. Rabaglia Angie T. Oler
Donnie S. Stapleton Kathryn L. Schueler Elias Chaibub Neto
Jee Young Moon Ping Wang I-Ming Wang Pek Yee Lum
Irena Ivanovska Michele Cleary Danielle Greenawalt John Tsang
Youn Jeong Choi Robert Kleinhanz Jin Shang Yun-Ping Zhou
Andrew D. Howard Bei B. Zhang Christina Kendziorski Nancy A. Thornberry
Brian S. Yandell Eric E. Schadt Alan D. Attie
Received: 22 July 2009 / Accepted: 14 August 2009 / Published online: 1 September 2009
Springer Science+Business Media, LLC 2009
Abstract Type 2 diabetes results from severe insulin
resistance coupled with a failure of b cells to compensate
by secreting sufficient insulin. Multiple genetic loci are
involved in the development of diabetes, although the
effect of each gene on diabetes susceptibility is thought to
be small. MicroRNAs (miRNAs) are noncoding 1922-
nucleotide RNA molecules that potentially regulate the
expression of thousands of genes. To understand the
relationship between miRNA regulation and obesity-


Source: Attie, Alan D. - Department of Biochemistry, University of Wisconsin at Madison
Yandell, Brian S. - Departments of Statistics & Horticulture, University of Wisconsin at Madison


Collections: Biology and Medicine; Mathematics