Home

About

Advanced Search

Browse by Discipline

Scientific Societies

E-print Alerts

Add E-prints

E-print Network
FAQHELPSITE MAPCONTACT US


  Advanced Search  

 
Amino acid and codon usage profiles: Adaptive changes in the frequency of amino acids and codons
 

Summary: Amino acid and codon usage profiles: Adaptive changes in the frequency of
amino acids and codons
Hani Goodarzi a,,1
, Noorossadat Torabi b,1
, Hamed Shateri Najafabadi b
, Marco Archetti c
a
Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
b
Department of Biotechnology, Faculty of Sciences, University of Tehran, Tehran, Iran
c
Department of Zoology, Oxford University, South Parks Road, OX1 3PS Oxford, UK
Received 4 March 2007; received in revised form 29 May 2007; accepted 24 September 2007
Available online 5 October 2007
Abstract
In the work presented, the changes in codon and amino acid contents have been studied as a function of environmental conditions by comparing pairs
of homologs in a group of extremophilic/non-extremophilic genomes. Our results obtained based on such analysis highlights a number of notable
observations: (i) the overall preference of amino acid usages in the proteins of a given organism is significantly affected by major environmental factors.
The changes in amino acid preferences (amino acid usage profiles) in an extremophile compared to its non-extremophile relative recurs in the organisms
of similar extreme habitats. (ii) On the other hand, changes in codon usage preferences in these extremophilic/non-extremophilic pairs, lack such

  

Source: Archetti, Marco - Department of Organismic and Evolutionary Biology, Harvard University

 

Collections: Biology and Medicine