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Cham et al. (JN-00369-2004.R1) Final Accepted Version -Page 1 of 14

Summary: Cham et al. (JN-00369-2004.R1)
Final Accepted Version - Page 1 of 14
1. Introduction
A fundamental challenge in experimental neurophysiol-
ogy and the development of brain-machine interfaces is
to record high quality action potentials from neuronal
populations. Since the development of the recording elec-
trode (Adrian 1926, Hubel 1957, Green 1958), two gen-
eral approaches have emerged: acute and chronic
recording methods. In acute recordings, individual elec-
trodes are advanced into tissue at the beginning of each
recording session through a cranial chamber, commonly
by devices termed microdrives. The electrodes are
advanced carefully until high quality neural activity is
found. During the course of an experiment, readjustment
of the electrode's position is often required to re-optimize
and maintain signal quality. While this method allows the
experimentalist flexibility in exploring different cell
types, the process of signal optimization consumes a sig-
nificant amount of time, even from an experienced opera-


Source: Andersen, Richard - Division of Biology, California Institute of Technology


Collections: Biology and Medicine