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Experience-dependent rescaling of entorhinal grids
 

Summary: Experience-dependent rescaling
of entorhinal grids
Caswell Barry14, Robin Hayman3,4, Neil Burgess1,2 &
Kathryn J Jeffery3,4
The firing pattern of entorhinal `grid cells' is thought to provide
an intrinsic metric for space. We report a strong experience-
dependent environmental influence: the spatial scales of the
grids (which are aligned and have fixed relative sizes within
each animal) vary parametrically with changes to a familiar
environment's size and shape. Thus grid scale reflects an
interaction between intrinsic, path-integrative calculation of
location and learned associations to the external environment.
`Grid cells' in dorsolateral medial entorhinal cortex (dlMEC) of freely
moving rats show regular grid-like patterns of firing across the
environment1 (Fig. 1). These are thought to provide an absolute metric
whereby an animal can update its own location using self-motion
information (`path integration')26. Accordingly, grid cells may provide
the path-integrative component to the representation of self-location
shown by hippocampal place cells24. Despite their apparent intrinsic
metric, grid cell firing is reproducible across trials1, indicating an

  

Source: Andrzejak, Ralph Gregor - Departament de Tecnologia, Universitat Pompeu Fabra
Burgess, Neil - Institute of Cognitive Neuroscience & Department of Anatomy and Developmental Biology, University College London

 

Collections: Biology and Medicine; Computer Technologies and Information Sciences