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Summary: Biological network models
Approaches used to understand the mechanisms behind the
evolution of molecular networks
Growth/ preferential attachment models: duplication of
genes, metabolic reactions, recombination, development
Comparative genomics/ pathway comparison across
phylogenetic tree
Predicting interactions based on existing information
Study the evolution of motifs and cliques
Evolving protein interaction networks
Genes and interactions among gene products have often been
conserved through evolution (orthologs).
We can consider the topology of protein interaction networks as a
result of a network evolution process.
One can formulate evolving network models for protein interaction
networks.
Driving forces behind the formation of edges:
gene duplication and mutation
protein attractiveness (affinity)
determined by protein (domain) structure
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