Home

About

Advanced Search

Browse by Discipline

Scientific Societies

E-print Alerts

Add E-prints

E-print Network
FAQHELPSITE MAPCONTACT US


  Advanced Search  

 
Biological network models Approaches used to understand the mechanisms behind the
 

Summary: Biological network models
Approaches used to understand the mechanisms behind the
evolution of molecular networks
­ Growth/ preferential attachment models: duplication of
genes, metabolic reactions, recombination, development
­ Comparative genomics/ pathway comparison across
phylogenetic tree
­ Predicting interactions based on existing information
­ Study the evolution of motifs and cliques
Evolving protein interaction networks
Genes and interactions among gene products have often been
conserved through evolution (orthologs).
We can consider the topology of protein interaction networks as a
result of a network evolution process.
One can formulate evolving network models for protein interaction
networks.
Driving forces behind the formation of edges:
gene duplication and mutation
protein attractiveness (affinity)
­ determined by protein (domain) structure

  

Source: Albert, Réka - Departments of Biology & Physics, Pennsylvania State University

 

Collections: Biology and Medicine