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Temporal Dynamics of Graded Synaptic Transmission in the Lobster Stomatogastric Ganglion
 

Summary: Temporal Dynamics of Graded Synaptic Transmission in the
Lobster Stomatogastric Ganglion
Yair Manor, Farzan Nadim, L. F. Abbott, and Eve Marder
Volen Center and Biology Department, Brandeis University, Waltham, Massachusetts 02254
Synaptic transmission between neurons in the stomatogastric
ganglion of the lobster Panulirus interruptus is a graded func-
tion of membrane potential, with a threshold for transmitter
release in the range of 50 to 60 mV. We studied the dynam-
ics of graded transmission between the lateral pyloric (LP)
neuron and the pyloric dilator (PD) neurons after blocking action
potential-mediated transmission with 0.1 M tetrodotoxin. We
compared the graded IPSPs (gIPSPs) from LP to PD neurons
evoked by square pulse presynaptic depolarizations with those
potentials evoked by realistic presynaptic waveforms of vari-
able frequency, amplitude, and duty cycle. The gIPSP shows
frequency-dependent synaptic depression. The recovery from
depression is slow, and as a result, the gIPSP is depressed at
normal pyloric network frequencies. Changes in the duration of
the presynaptic depolarization produce nonintuitive changes in
the amplitude and time course of the postsynaptic responses,

  

Source: Abbott, Laurence - Center for Neurobiology and Behavior & Department of Physiology and Cellular Biophysics, Columbia University
Nadim, Farzan - Federated Department of Biological Sciences, Rutgers University at Newark

 

Collections: Biology and Medicine; Mathematics