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Notch1 and the activated NOTCH1 intracellular domain are expressed in differentiated trophoblast cells
 

Summary: Notch1 and the activated NOTCH1 intracellular domain are
expressed in differentiated trophoblast cells
Didem Pelin Sarikaya*,{
and Loydie Anne Jerome-Majewska1
*,{
* Department of Human Genetics, McGill University, Montreal Children's Hospital, Montreal, Quebec, Canada
{
Organismic and Evolutionary Biology Department, Harvard University, Cambridge, MA, USA
{
Department of Pediatrics, McGill University, Montreal Children's Hospital, Montreal, Quebec, Canada
Abstract
The Notch signalling pathway regulates proliferation, cell death and cell type specification that is critical for organogenesis.
Mouse models carrying mutations in the Notch signalling pathway display defects in development of the placenta,
suggesting that this pathway is required for placental development. In particular, Notch1 mutant embryos exhibit abnormal
placental morphogenesis and arrest early in development. However, expression of Notch1 gene has not been detected
during placental development. Trophoblast stem cells are derived from the precursor of the placenta and express Notch1.
We report that Notch1 is also expressed in differentiated trophoblast cells. Under standard differentiation conditions,
Notch1 expression ceases by day 6. Furthermore, the activated NOTCH1 intracellular domain is enriched at the nucleolus
of trophoblast stem cells and differentiated trophoblast cells. Our results suggest that NOTCH1 is active in both trophoblast
stem cells and differentiated trophoblast cells.

  

Source: Alwes, Frederike - Department of Organismic and Evolutionary Biology, Harvard University

 

Collections: Biology and Medicine