Biochemical parameters in BHcB mice. Blood was collected after a 4h fast
from TXNIP-deficient C57BL/6.hcb and control C57BL/6 mice and analyzed for
(A) triglycerides, (B) ketones and (C) glucose. Bars represent means ±SEM,
n=number of mice used per group.
Induction of Akt/Bcl-xL signaling in TXNIP-deficient mice. Pancreata of 12
week-old obese and diabetic BTBR.ob and congenic TXNIP-deficient
BTBR.ob/hcb mice were analyzed by immunohistochemistry for (A) cleaved
caspase-9 and (B) Bcl-xL. Isolated islets of C3H and Hcb-19 mice were used for
immunoblotting to quantify the expression of (C) p-Akt and (D) total Akt; bars
represent means ±SEM, at least 3 independent experiments were performed;
insert: representative immunoblot.
Comparison of Weight and Adiposity in 16-week old TXNIPdeficient HcB-19 (HcB) versus
Control C3H Mice
C3H HcB p-value*
means ± (SEM) means ± (SEM) HcB vs C3H