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The mechanisms underlying chronic osteoarthritis (OA) pain remain obscure.
 

Summary: The mechanisms underlying chronic
osteoarthritis (OA) pain remain obscure.
In this study we examine the role of the
cerebral cortex in OA pain using fMRI,
by identifying brain activity in response
to an acute painful pressure stimulus to
the arthritic knee. We also contrast
these findings with brain activity
patterns for spontaneous chronic back
pain (CBP) , and acute thermal pain in
normal subjects.
INTRODUCTION
6 patients with knee OA were scanned
while receiving painful pressure stimuli to
both knees, one knee at a time.
Patients were trained to use the finger-
span device to rate magnitude of either
their spontaneous pain, or that of a
moving bar (motor-cognitive control)
(panel 1).

  

Source: Apkarian, A. Vania - Department of Physiology, Northwestern University

 

Collections: Biology and Medicine