Summary: Published online 8 May 2009 Nucleic Acids Research, 2009, Vol. 37, Web Server issue W189­W192
doi:10.1093/nar/gkp320
SROOGLE: webserver for integrative, user-friendly
visualization of splicing signals
Schraga Schwartz, Eitan Hall and Gil Ast*
Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel-Aviv University,
Ramat Aviv 69978, Israel
Received January 29, 2009; Revised April 7, 2009; Accepted April 20, 2009
ABSTRACT
Exons are typically only 140 nt in length and are sur-
rounded by intronic oceans that are thousands of
nucleotides long. Four core splicing signals, aided
by splicing-regulatory sequences (SRSs), direct the
splicing machinery to the exon/intron junctions.
Many different algorithms have been developed to
identify and score the four splicing signals and thou-
sands of putative SRSs have been identified, both
computationally and experimentally. Here we
describe SROOGLE, a webserver that makes spli-
cing signal sequence and scoring data available to

Source: Ast, Gil - Department of Molecular Genetics and Biochemistry, Tel Aviv University

Collections: Biology and Medicine