Summary: CHAPTER 4
The Role of Mechanistic Factors
in Promoting Chromosomal
Translocations Found in
Lymphoid and Other Cancers
Yu Zhang,*,,,§
Monica Gostissa,*,,,§
Dominic G. Hildebrand,*,,,§
Michael S. Becker,*,,,§
Cristian Boboila,*,,,§
Roberto Chiarle,*,,,§
Susanna Lewis,*,,,§
and Frederick W. Alt*,,,§
Contents 1. Chromosomal Translocations in Cancer 95
1.1. Overview 95
1.2. Oncogenic translocations in cancer frequently
have DSB intermediates 96
1.3. Chromosomal translocations in hematological
malignancies 96
1.4. Chromosomal translocations in epithelial tumors 98

Source: Alt,, Frederick - Immune Disease Institute, Harvard University

Collections: Biology and Medicine