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Summary: Analysis of Pseudomonas aeruginosa diguanylate
cyclases and phosphodiesterases reveals a role for
bis-(3 -5 )-cyclic-GMP in virulence
Hemantha Kulesekara*
, Vincent Lee*
, Anja Brencic*, Nicole Liberati§
, Jonathan Urbach§
, Sachiko Miyata§
,
Daniel G. Lee§
, Alice N. Neely¶
, Mamoru Hyodo , Yoshihiro Hayakawa , Frederick M. Ausubel§
**, and Stephen Lory*,
**
Departments of *Microbiology and Molecular Genetics and Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115; §Department
of Molecular Biology, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114; ¶Shriners Hospital for Children, 3229 Burnet Avenue,
Cincinnati, OH 45229; and Graduate School of Information Science Human Informatics and Core Research for Evolutional Science and Technology of the
Japan Science and Technology Agency, Nagoya University, Chikusa, Nagoya 464-8601, Japan
Contributed by Frederick M. Ausubel, December 22, 2005
The opportunistic pathogen Pseudomonas aeruginosa is responsi-
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