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Different levels of alternative splicing among Eddo Kim, Alon Magen and Gil Ast*
 

Summary: Different levels of alternative splicing among
eukaryotes
Eddo Kim, Alon Magen and Gil Ast*
Department of Human Genetics and Molecular Medicine, Sackler Faculty of Medicine, Tel Aviv University,
Ramat Aviv 69978, Israel
Received September 7, 2006; Revised October 9, 2006; Accepted October 17, 2006
ABSTRACT
Alternative splicing increases transcriptome and
proteome diversification. Previous analyses aiming
at comparing the rate of alternative splicing between
different organisms provided contradicting results.
These contradicting results were attributed to the
fact that both analyses were dependent on the ex-
pressed sequence tag (EST) coverage, which varies
greatly between the tested organisms. In this study
we compare the level of alternative splicing among
eight different organisms. By employing an EST
independent approach we reveal that the percentage
of genes and exons undergoing alternative splicing
is higher in vertebrates compared with inverte-

  

Source: Ast, Gil - Department of Molecular Genetics and Biochemistry, Tel Aviv University

 

Collections: Biology and Medicine