Summary: 545
Laboratory evolutionists continue to generate better enzymes for
industrial and research applications. Exciting developments include
new biocatalysts for enantioselective carbon­carbon bond
formation and fatty acid production in plants. Creative contributions
to the repertoire of evolutionary methods will ensure further growth
in applications and expand the scope and complexity of biological
design problems that can be addressed. Researchers are also
starting to elucidate mechanisms of enzyme adaptation and natural
evolution by testing evolutionary scenarios in the laboratory.
Addresses
Division of Chemistry and Chemical Engineering 210-41,
California Institute of Technology, Pasadena, CA 91125, USA;
e-mail: frances@cheme.caltech.edu
*These authors contributed equally to this work.
Current Opinion in Biotechnology 2001, 12:545­551
0958-1669/01/$ -- see front matter
© 2001 Elsevier Science Ltd. All rights reserved.
Abbreviations
CSR compartmentalized self-replication

Source: Arnold, Frances H. - Division of Chemistry and Chemical Engineering, California Institute of Technology

Collections: Chemistry; Biology and Medicine