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Human Cardiac High-Energy Phosphate Metabolite Concentrationsby ID-Resolved NMR Spectroscopy

Summary: Human Cardiac High-Energy Phosphate Metabolite
Concentrationsby ID-Resolved NMR Spectroscopy
Paul A. Bottomley, Ergin Atalar, Robert G. Weiss
We have developed a method that can measure high-energy
phosphate metabolite concentrations in humans with 1D re-
solved surface-coil NMR spectroscopy. The metabolites are
measured by phosphorus e'P) NMR spectroscopy, and the
tissue water proton (lH) resonance from the same volume
serves as an internal concentration reference. The method
requiresonly the additional acquisition of a 'H data set, and a
simple calibration, performed separately, to determine the
ratio of the signal per proton to the signal per phosphorus
nucleus. The quantification method is particularly useful for
human cardiac spectroscopy, where it eliminates image-
based tissue volumetry and the corrections for signal sensi-
tivity and phasenonuniformitynecessaryinprior approaches.
Corrections are introduced to account for blood and fat con-
tributions to the spectra. The method was validatedon phan-
toms of phosphate of varying concentrations and on the hu-
mancalf muscle. Incalf, the adenosinetriphosphate(ATP)and


Source: Atalar, Ergin - Department of Electrical and Electronics Engineering, Bilkent University


Collections: Engineering; Biology and Medicine