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Multiple Solenoidal Microcoil Probes for High-Sensitivity, High-Throughput Nuclear

Summary: Multiple Solenoidal Microcoil Probes for
High-Sensitivity, High-Throughput Nuclear
Magnetic Resonance Spectroscopy
Y. Li, A. M. Wolters, P. V. Malawey, J. V. Sweedler,, and A. G. Webb*,,
Department of Electrical and Computer Engineering, School of Chemical Sciences, and Beckman Institute for Advanced
Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801
Two designs for incorporating multiple solenoidal micro-
coils into a single probe head are presented to increase
the throughput of high-resolution NMR. Through a com-
bination of radio frequency switches and low-noise ampli-
fiers, multiple NMR spectra can be acquired in the same
time as a single spectrum from a conventional probe
consisting of one coil. Since this method does not com-
promise sensitivity with regard to the individual micro-
coils, throughput increases linearly with the number of
coils. Only one receiver is needed, and data acquisition
parameters can be optimized for each sample. Specifically,
a four-coil system has been implemented for proton NMR
at 250 MHz using a wide-bore magnet, with an observe
volume of 28 nL for each microcoil. Signal cross-


Source: Andrews, Anne M. - Huck Institutes of the Life Sciences, Pennsylvania State University


Collections: Biology and Medicine