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Summary: Library analysis of SCHEMA-guided
protein recombination
MICHELLE M. MEYER,1,4
JONATHAN J. SILBERG,1,4
CHRISTOPHER A. VOIGT,3
JEFFREY B. ENDELMAN,1
STEPHEN L. MAYO,2
ZHEN-GANG WANG,1
AND
FRANCES H. ARNOLD1
1
Division of Chemistry and Chemical Engineering, and 2
Howard Hughes Medical Institute and Division of Biology,
California Institute of Technology, Pasadena, California 91125, USA
3
Department of Bioengineering, University of California, Berkeley, California 94720, USA
(RECEIVED February 17, 2003; FINAL REVISION May 1, 2003; ACCEPTED May 1, 2003)
Abstract
The computational algorithm SCHEMA was developed to estimate the disruption caused when amino acid
residues that interact in the three-dimensional structure of a protein are inherited from different parents upon
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