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Redundancy Reduction and Sustained Firing with Stochastic Depressing Synapses
 

Summary: Redundancy Reduction and Sustained Firing with Stochastic
Depressing Synapses
Mark S. Goldman,1,3 Pedro Maldonado,4 and L. F. Abbott1,2
1
Volen Center and 2
Department of Biology, Brandeis University, Waltham, Massachusetts 02454, 3
Department of
Physics, Harvard University, Cambridge, Massachusetts 02138, and 4
Facultad de Medicina, Instituto de Ciencias
Biomedicas, Universidad de Chile, Santiago, Chile
Many synapses in the CNS transmit only a fraction of the action
potentials that reach them. Although unreliable, such synapses
do not transmit completely randomly, because the probability
of transmission depends on the recent history of synaptic
activity. We examine how a variety of spike trains, including
examples recorded from area V1 of monkeys freely viewing
natural scenes, are transmitted through a realistic model syn-
apse with activity-dependent depression arising from vesicle
depletion or postrelease refractoriness. The resulting se-
quences of transmitted spikes are significantly less correlated,

  

Source: Abbott, Laurence - Center for Neurobiology and Behavior & Department of Physiology and Cellular Biophysics, Columbia University

 

Collections: Biology and Medicine