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Behavioral/Systems/Cognitive Different Forms of Self-Control Share a Neurocognitive
 

Summary: Behavioral/Systems/Cognitive
Different Forms of Self-Control Share a Neurocognitive
Substrate
Golnaz Tabibnia,1 John R. Monterosso,1 Kate Baicy,1 Adam R. Aron,2 Russell A. Poldrack,2,3 Shruthi Chakrapani,1
Buyean Lee,1 and Edythe D. London1,3,4
Departments of 1Psychiatry and Biobehavioral Sciences, 2Psychology, and 3Molecular and Medical Pharmacology, and 4Brain Research Institute, University
of California, Los Angeles, California 90024
Psychological and neurocognitive studies have suggested that different kinds of self-control may share a common psychobiological
component.Ifthisistrue,performanceinaffectiveandnonaffectiveinhibitorycontroltasksinthesameindividualsshouldbecorrelated
and should rely upon integrity of this region. To test this hypothesis, we acquired high-resolution magnetic resonance images from 44
healthy and 43 methamphetamine-dependent subjects. Individuals with methamphetamine dependence were tested because of prior
findings that they suffer inhibitory control deficits. Gray matter structure of the inferior frontal gyrus was assessed using voxel-based
morphometry. Subjects participated in tests of motor and affective inhibitory control (stop-signal task and emotion reappraisal task,
respectively); and methamphetamine-dependent subjects provided self-reports of their craving for methamphetamine. Performance
levels on the two inhibitory control tasks were correlated with one another and with gray matter intensity in the right pars opercularis
region of the inferior frontal gyrus in healthy subjects. Gray matter intensity of this region was also correlated with methamphetamine
craving. Compared with healthy subjects, methamphetamine-dependent subjects exhibited lower gray matter intensity in this region,
worse motor inhibitory control, and less success in affect regulation. These findings suggest that self-control in different psychological
domainsinvolvesacommonsubstrateintherightparsopercularis,andthatsuccessfulself-controldependsonintegrityofthissubstrate.
Introduction

  

Source: Aron, Adam - Department of Psychology, University of California at San Diego

 

Collections: Biology and Medicine