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BioMed Central Page 1 of 12

Summary: BioMed Central
Page 1 of 12
(page number not for citation purposes)
BMC Evolutionary Biology
Open AccessResearch article
DNA indels in coding regions reveal selective constraints on protein
evolution in the human lineage
Nicole de la Chaux*1,2, Philipp W Messer1 and Peter F Arndt1
Address: 1Department for Computational Molecular Biology, Max-Planck-Institute for Molecular Genetics, Ihnestr. 63-73, 14195 Berlin, Germany
and 2Department for Biochemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zürich, Switzerland
Email: Nicole de la Chaux* - n.delachaux@bioc.unizh.ch; Philipp W Messer - philipp.messer@molgen.mpg.de;
Peter F Arndt - arndt@molgen.mpg.de
* Corresponding author
Background: Insertions and deletions of DNA segments (indels) are together with substitutions
the major mutational processes that generate genetic variation. Here we focus on recent DNA
insertions and deletions in protein coding regions of the human genome to investigate selective
constraints on indels in protein evolution.
Results: Frequencies of inserted and deleted amino acids differ from background amino acid
frequencies in the human proteome. Small amino acids are overrepresented, while hydrophobic,


Source: Arndt, Peter - Max-Planck-Institut für molekulare Genetik
Spang, Rainer - Computational Molecular Biology Group, Max-Planck-Institut für molekulare Genetik


Collections: Biology and Medicine; Biotechnology; Computer Technologies and Information Sciences; Physics