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Microfluidic devices for terahertz spectroscopy of biomolecules
 

Summary: Microfluidic devices for terahertz
spectroscopy of biomolecules
Paul A. George1, Wallace Hui1, Farhan Rana1, Benjamin G. Hawkins2,
A. Ezekiel Smith3, Brian J. Kirby4
1
School of Electrical and Computer Engineering, Cornell University, Ithaca, NY, 14853
2Department of Biomedical Engineering, Cornell University, Ithaca, NY, 14853
3School of Applied and Engineering Physics, Cornell University, Ithaca, NY, 14853
4School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY, 14853
pag25@cornell.edu
Abstract: We demonstrate microfluidic devices for terahertz spectroscopy
of biomolecules in aqueous solutions. The devices are fabricated out of a
plastic material that is both mechanically rigid and optically transparent
with near-zero dispersion in the terahertz frequency range. Using a low-
power terahertz time-domain spectrometer, we experimentally measure
the absorption spectra of the vibrational modes of bovine serum albumin
from 0.5 - 2.5 THz and find good agreement with previously reported
data obtained using large-volume solutions and a high-power free-electron
laser. Our results demonstrate the feasibility of performing high sensitivity
terahertz spectroscopy of biomolecules in aqueous solutions with detectable

  

Source: Afshari, Ehsan - School of Electrical and Computer Engineering, Cornell University

 

Collections: Engineering