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Communication Improved time efficiency and accuracy in diffusion tensor

Summary: Communication
Improved time efficiency and accuracy in diffusion tensor
microimaging with multiple-echo acquisition
Vikas Gulani a,b,*, Thomas Weber a
, Thomas Neuberger a
, Andrew G. Webb a,c
Experimentelle Physik 5, Physikalisches Institut, Universita®t Wu®rzburg, Am Hubland, 97074 Wu®rzburg, Germany
Department of Radiology, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, MI 48109-0030, USA
Department of Bioengineering, 206 Hallowell Building, Penn State University, University Park, PA 16802, USA
Received 21 December 2004; revised 19 August 2005
Available online 23 September 2005
In high-field NMR microscopy rapid single-shot imaging methods, for example, echo planar imaging, cannot be used for determina-
tion of the apparent diffusion tensor (ADT) due to large magnetic susceptibility effects. We propose a pulse sequence in which a diffusion-
weighted spin-echo is followed by multiple gradient-echoes with additional diffusion weighting. These additional echoes can be used to
calculate the ADT and T√
2 maps. We show here that this results in modest but consistent improvements in the accuracy of ADT deter-


Source: Andrews, Anne M. - Huck Institutes of the Life Sciences, Pennsylvania State University


Collections: Biology and Medicine