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S1296-2147(01)01230-6/FLA AID:1230 Vol.2(6) P.1 (1-7) CRAcad 2001/05/17 Prn:8/06/2001; 11:57 F:PXHY1230.tex by:ELE p. 1
 

Summary: S1296-2147(01)01230-6/FLA AID:1230 Vol.2(6) P.1 (1-7)
CRAcad 2001/05/17 Prn:8/06/2001; 11:57 F:PXHY1230.tex by:ELE p. 1
C. R. Acad. Sci. Paris, t. 2, Série IV, p. 1­7, 2001
Biophysique/Biophysics
(Physique statistique, thermodynamique/Statistical physics, thermodynamics)
DOSSIER
LA PHYSIQUE À L'ÉCHELLE DE LA CELLULE
THE PHYSICS AT THE SCALE OF THE CELL
Robust amplification in adaptive signal transduction
networks
Naama BARKAI, Uri ALON, Stanislas LEIBLER
Departments of Physics and Molecular Biology, Princeton University, Princeton, NJ 08544, USA
E-mail: barkai@weizmann.ac.il; urialon@wisemail.weizmann.ac.il; stanislas.leibler@molbio.princeton.edu
(Reçu le 10 mars 2001, accepté le 10 mai 2001)
Abstract. Amplification of small changes in input signals is an essential feature of many biological
signal transduction systems. An important problem is how sensitivity amplification can be
reconciled with wide dynamic range of response. Here a general molecular mechanism is
proposed, in which both high amplification and wide dynamic range of a sensory system
is obtained, and this without fine-tuning of biochemical parameters. The amplification
mechanism is based on inhibition of the enzymatic activity of the sensory complex. As

  

Source: Alon, Uri - Departments of Molecular Cell Biology & Physics of Complex Systems, Weizmann Institute of Science
Barkai, Naama - Departments of Molecular Genetics & Physics of Complex Systems, Weizmann Institute of Science

 

Collections: Biology and Medicine; Biotechnology