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Summary: The Center for Control, Dynamical Systems, and Computation
University of California at Santa Barbara
Winter 2008 Systems Biology
Seminar Series Presents
Modeling, Analysis and Control of the Translational
Initiation Regulation Process in Eukaryotic Cells
Nadi Skjøndal-Bar
Norwegian University of Science and Technology
Friday, February 29, 2008 3:00-4:00pm Harold Frank Hall 1104
Abstract:
It was found in the last decade that gene regulation in the level of translation is
mainly effected by the initiation process. Eukaryotic initiation factors (eIF-) 2 and
4 are the main components that regulate gene expression, by enabling the 40S
ribosomal subunit structure to bind to a pre-initiation complex eIF-4F. This process
is complex and involves many different regulating components. This paper pres-
ents models for the eIF-2 and -4 regulation processes. A further simplification of
the eIF-2 process is presented and nonlinear analysis proves L2 stability of the
process. Simulations and analysis of the reduced model led to several conclusions
about the affect of a few principle factors in the eIF-2 initiation process (namely
eIF-2B, phosphorylated and non-phosphorylated eIF-2_ and GCN2), consistent
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