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Mol. Biol. Evol. 18(3):291298. 2001 2001 by the Society for Molecular Biology and Evolution. ISSN: 0737-4038
 

Summary: 291
Mol. Biol. Evol. 18(3):291298. 2001
2001 by the Society for Molecular Biology and Evolution. ISSN: 0737-4038
Recombination and the Frequency Spectrum in Drosophila melanogaster
and Drosophila simulans
Molly Przeworski,* Jeffrey D. Wall, and Peter Andolfatto
*Department of Statistics, Oxford University, Oxford, England; 2102 Biological Laboratories, Harvard University; and
Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh, Scotland
Most ``tests of neutrality'' assess whether particular data sets depart from the predictions of a standard neutral model
with no recombination. For Drosophila, where nuclear polymorphism data routinely show evidence of genetic
exchange, the assumption of no recombination is often unrealistic. In addition, while conservative, this assumption
is made at the cost of a great loss in power. Perhaps as a result, tests of the frequency spectrum based on zero
recombination suggest an adequate fit of Drosophila polymorphism data to the predictions of the standard neutral
model. Here, we analyze the frequency spectrum of a large number of loci in Drosophila melanogaster and D.
simulans using two summary statistics. We use an estimate of the population recombination rate based on a labo-
ratory estimate of the rate of crossing over per physical length and an estimate of the species' effective population
size. In contrast to previous studies, we find that roughly half of the loci depart from the predictions of the standard
neutral model. The extent of the departure depends on the exact recombination rate, but the global pattern that
emerges is robust. Interestingly, these departures from neutral expectations are not unidirectional. The large variance
in outcomes may be due to a complex demographic history and inconsistent sampling, or to the pervasive action

  

Source: Andolfatto, Peter - Department of Ecology and Evolutionary Biology, Princeton University

 

Collections: Biology and Medicine