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MATHEMATICAL MORPHOLOGY OPERATORS FOR READING RADIOACTIVITY DNA ARRAY IMAGES
 

Summary: MATHEMATICAL MORPHOLOGY OPERATORS FOR READING
RADIOACTIVITY DNA ARRAY IMAGES
Jes´us Angulo
Centre de Morphologie Math´ematique
Ecole des Mines de Paris,
35, rue Saint-Honor´e, 77305 Fontainebleau, FRANCE
angulo@cmm.ensmp.fr ;http://cmm.ensmp.fr/angulo
ABSTRACT
We have recently proposed an automatic non-supervised
set of algorithms for an accurate spot data extraction from
Cy3/Cy5 cDNA microarrays using morphological opera-
tors. On the basis of an image signal intensity model, we
explore in this study the application of advanced morpho-
logical filters for the spot determination and the spot signal
quantification on radio-labelled cDNA arrays. The idea be-
hind the approach here developed is to use the connected
operators like area and contrast opening, adaptively applied
according to the image features (size of spots, background
estimate, etc.), for defining a zone of the positive spots
where computing effectively the spot intensity without the

  

Source: Angulo,Jesús - Centre de Morphologie Mathématique, Ecole des Mines de Paris

 

Collections: Computer Technologies and Information Sciences