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Mechanisms promoting translocations in editing and switching peripheral B cells
 

Summary: ARTICLES
Mechanisms promoting translocations in
editing and switching peripheral B cells
Jing H. Wang1,2,3,4
*, Monica Gostissa1,2,3,4
*, Catherine T. Yan1,2,3,4
*, Peter Goff1,2,3,4
, Thomas Hickernell1,2,3,4
,
Erica Hansen1,2,3,4
, Simone Difilippantonio5
, Duane R. Wesemann1,2,3,4,6
, Ali A. Zarrin1,2,3,4
{, Klaus Rajewsky3
,
Andre Nussenzweig5
& Frederick W. Alt1,2,3,4
Variable, diversity and joining gene segment (V(D)J) recombination assembles immunoglobulin heavy or light chain (IgH or
IgL) variable region exons in developing bone marrow B cells, whereas class switch recombination (CSR) exchanges IgH
constant region exons in peripheral B cells. Both processes use directed DNA double-strand breaks (DSBs) repaired by

  

Source: Alt,, Frederick - Immune Disease Institute, Harvard University

 

Collections: Biology and Medicine