| | |
Summary: Neuron
Article
Calcium Store Depletion Induces Persistent
Perisomatic Increases in the Functional Density
of h Channels in Hippocampal Pyramidal Neurons
Rishikesh Narayanan,1,2 Kevin J. Dougherty,1 and Daniel Johnston1,*
1Center for Learning and Memory, The University of Texas at Austin, Austin, TX 78712, USA
2Present address: Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560012, India
*Correspondence: djohnston@mail.clm.utexas.edu
DOI 10.1016/j.neuron.2010.11.033
SUMMARY
The regulation of intracellular calcium by the endo-
plasmic reticulum (ER) plays a critical role in neuronal
function. While the consequences associated with
depleting calcium from the ER have been studied in
multiple systems, it is not known whether the intrinsic
properties of a neuron change in response to such
perturbations. In this study, we demonstrate that
the depletion of calcium from the ER of hippocampal
CA1 pyramidal neurons induces a persistent, periso-
|
