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INSTITUTE OF PHYSICS PUBLISHING PHYSICAL BIOLOGY Phys. Biol. 2 (2005) 8188 doi:10.1088/1478-3975/2/2/001
 

Summary: INSTITUTE OF PHYSICS PUBLISHING PHYSICAL BIOLOGY
Phys. Biol. 2 (2005) 8188 doi:10.1088/1478-3975/2/2/001
Environmental selection of the
feed-forward loop circuit in
gene-regulation networks
Erez Dekel, Shmoolik Mangan and Uri Alon
Department of Molecular Cell Biology and Department of Physics of Complex Systems,
The Weizmann Institute of Science, Rehovot, 76100, Israel
E-mail: urialon@weizmann.ac.il
Received 23 December 2004
Accepted for publication 31 March 2005
Published 28 April 2005
Online at stacks.iop.org/PhysBio/2/81
Abstract
Gene-regulation networks contain recurring elementary circuits termed network motifs. It is of
interest to understand under which environmental conditions each motif might be selected. To
address this, we study one of the most significant network motifs, a three-gene circuit called
the coherent feed-forward loop (FFL). The FFL has been demonstrated theoretically and
experimentally to perform a basic information-processing function: it shows a delay following
ON steps of an input inducer, but not after OFF steps. Here, we ask under what environmental

  

Source: Alon, Uri - Departments of Molecular Cell Biology & Physics of Complex Systems, Weizmann Institute of Science

 

Collections: Biology and Medicine