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INFECTION AND IMMUNITY, Aug. 1995, p. 28922898 Vol. 63, No. 8 0019-9567/95/$04.00 0
 

Summary: INFECTION AND IMMUNITY, Aug. 1995, p. 28922898 Vol. 63, No. 8
0019-9567/95/$04.00 0
Copyright 1995, American Society for Microbiology
Fine Specificity of the Genetically Controlled Immune Response to
Native and Recombinant gp15/400 (Polyprotein Allergen)
of Brugia malayi
JUDITH E. ALLEN,* RACHEL A. LAWRENCE, AND RICK M. MAIZELS
Wellcome Research Centre for Parasitic Infections, Department of Biology,
Imperial College, London, United Kingdom
Received 23 March 1995/Returned for modification 5 May 1995/Accepted 22 May 1995
Polyprotein allergens are a family of structurally homologous molecules from parasitic nematodes which
induce specific immunoglobulin E in infected individuals. We show here that both H-2 and non-H-2 factors
determine the ability of mice to generate T- and B-cell responses to the filarial polyprotein allergen (Brugia
malayi gp15/400). Further, H-2 and non-H-2 genes can complement one another to overcome nonresponsive-
ness to this molecule. However, these genetic restrictions govern only responses to the native glycoprotein and
all strains of mice respond equivalently when immunized with a recombinant polypeptide. Overlapping
fragments of gp15/400 were constructed to compare the T-cell and antibody responses to native versus
recombinant gp15/400 in responder (BALB/c H-2d
) and nonresponder (B10.D2 H-2d
, CBA H-2k

  

Source: Allen, Judith - School of Biological Sciences, University of Edinburgh

 

Collections: Biology and Medicine