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Molecular Biology of the Cell Vol. 11, 819831, March 2000

Summary: Molecular Biology of the Cell
Vol. 11, 819831, March 2000
Clathrin-mediated Endocytosis of MUC1 Is Modulated
by Its Glycosylation State
Yoram Altschuler,* Carol L. Kinlough,
Paul A. Poland,
James B. Bruns,
Gerard Apodaca,
Ora A. Weisz,
and Rebecca P. Hughey
*Department of Anatomy, University of California San Francisco, San Francisco, California 94143; and

Laboratory of Epithelial Cell Biology, Department of Medicine, Renal-Electrolyte Division, University
of Pittsburgh, Pittsburgh, Pennsylvania 15261
Submitted November 8, 1999; Accepted December 21, 1999
Monitoring Editor: Suszanne Pfeffer
MUC1 is a mucin-like type 1 transmembrane protein associated with the apical surface of
epithelial cells. In human tumors of epithelial origin MUC1 is overexpressed in an underglyco-
sylated form with truncated O-glycans and accumulates in intracellular compartments. To un-
derstand the basis for this altered subcellular localization, we compared the synthesis and


Source: Apodaca, Gerard - Departments of Medicine & Cell Biology and Physiology, University of Pittsburgh


Collections: Biology and Medicine