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the direction of their migration. They found that ectopicTwo Signals Are Better Than One: expression of a gene homologous to mammalian PDGF
 

Summary: Previews
443
the direction of their migration. They found that ectopicTwo Signals Are Better Than One:
expression of a gene homologous to mammalian PDGF
Border Cell Migration in Drosophila and VEGF ligands resulted in inefficient border cell mi-
gration. Based on homology, they then identified the
Drosophila homolog of the PDGF/VEGF receptor and
showed that the ligand, called PVF1, could bind to and
Recent studies of border cell migration during Dro-
activate the receptor (PVR) in vitro. When the expression
sophila oogenesis demonstrate that the EGFR and
of the two genes was examined, PVF1 was found to be
PDGFR signaling pathways act in a partially redundant
concentrated in the oocyte during border cell migration,
manner to guide this process. Evidence presented
while PVR was expressed in all of the follicle cells. This
shows that PDGFR signaling directs border cell migra-
suggested that PVF1 is secreted from the oocyte, pro-
tion via Rac and the Rac activator Mbc/CED-5/
viding a gradient of ligand that binds to the PVR recep-

  

Source: Alwes, Frederike - Department of Organismic and Evolutionary Biology, Harvard University

 

Collections: Biology and Medicine