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Dynamic gene expression is required for anterior regionalization in a spider
 

Summary: Dynamic gene expression is required for anterior
regionalization in a spider
Matthias Pechmann1
, Alistair P. McGregor2
, Evelyn E. Schwager, NataŽlia M. Feitosa3
, and Wim G. M. Damen4
Department of Evolutionary Genetics, Institute for Genetics, University of Cologne, Zuš lpicher Strasse 47, 50674 Koš ln, Germany
Edited by Sean B. Carroll, University of Wisconsin, Madison, WI, and approved December 12, 2008 (received for review November 4, 2008)
Patterning of a multicellular embryo requires precise spatiotem-
poral control of gene expression during development. The gradient
of the morphogen bicoid regulates anterior regionalization in the
syncytial blastoderm of Drosophila. However many arthropod
embryos develop from a cellular blastoderm that does not allow
the formation of transcription factor gradients. Here we show that
correct anterior development of the cellularized embryo of the
spider Achaearanea tepidariorum requires an anterior-to-posterior
wave of dynamic gene expression for positioning the stripes of
hairy, hedgehog, and orthodenticle expression. Surprisingly, this
dynamic repositioning of the expression of these segmentation
genes is blocked in orthodenticlepRNAi embryos and no anterior

  

Source: Alwes, Frederike - Department of Organismic and Evolutionary Biology, Harvard University

 

Collections: Biology and Medicine