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Realistic Simulation of the 3D Growth of Brain Tumors in MR Images Coupling Diffusion with
 

Summary: 1
Realistic Simulation of the 3D Growth of Brain
Tumors in MR Images Coupling Diffusion with
Biomechanical Deformation
Olivier Clatz, Maxime Sermesant, Pierre-Yves Bondiau, HervŽe Delingette, Simon K. Warfield,
GrŽegoire Malandain, Nicholas Ayache
Epidaure Research Project, INRIA Sophia Antipolis, France
Centre Antoine Lacassagne, Nice, France
Computational Radiology Laboratory,
Brigham and Women's Hospital, Children's Hospital, Harvard Medical School, Boston, USA
Abstract-- We propose a new model to simulate the 3D growth
of glioblastomas multiforma (GBMs), the most aggressive glial
tumors. The GBM speed of growth depends on the invaded tissue:
faster in white than in gray matter, it is stopped by the dura
or the ventricles. These different structures are introduced into
the model using an atlas matching technique. The atlas includes
both the segmentations of anatomical structures and diffusion
information in white matter fibers.
We use the finite element method (FEM) to simulate the
invasion of the GBM in the brain parenchyma and its mechanical

  

Source: Ayache, Nicholas - INRIA

 

Collections: Computer Technologies and Information Sciences; Engineering