| | |
Summary: Nanobiosensors
Constraint of DNA on Functionalized Graphene Improves
its Biostability and Specificity**
Zhiwen Tang, Hong Wu, John R. Cort, Garry W. Buchko, Youyu Zhang, Yuyan Shao,
Ilhan A. Aksay, Jun Liu, and Yuehe Lin*
Graphene, a single-layer carbon crystal, is attracting increasing
attention from the physical, chemical, and biomedical fields[1]
as a novel nanomaterial with many exceptional features
including excellent electrical conductivity, high surface-to-
volume ratio, remarkable mechanical strength, and biocompa-
tibility.[1a,c,,2]
Recently, functionalized graphene has been
successfully used in many biomedical and bioassay applications
and shows promising potentials in these fields. For instance, Liu
et al. used PEGylated graphene oxide for delivery of water-
insoluble cancer drugs to cancer cells.[1f]
The Berry group
demonstrated a graphene-based biodevice for bacterium assay
and DNA detection.[3]
Lu et al. designed a graphene-based
|
