Summary: 650
Carbohydrate materials have become increasingly utilized in
transplantation and cell/tissue engineering within the past year.
This has been well documented in recent applications of
immobilized or soluble -galactosyl epitopes
(i.e. oligosaccharides with a terminal Gal1­3Gal sequence)
in preventing hyperacute rejection in pig-to-primate
xenotransplantation. In addition, -galactosyl polymers have
been shown to exhibit much greater activity (up to 104 times)
than -galactosyl monomers in inhibiting the binding of anti-
galactosyl antibodies to pig kidney epithelial cells and assisting
in the prevention of cytotoxicity in human serum.
Addresses
Department of Chemistry, Wayne State University, Detroit, MI 48202,
USA
*e-mail: pwang@chem.wayne.edu
Correspondence: Peng George Wang
Current Opinion in Chemical Biology 1999, 3:650­658
1367-5931/99/$ -- see front matter © 1999 Elsevier Science Ltd.
All rights reserved.

Source: Andreana, Peter R. - Department of Chemistry, Wayne State University
Chen, Xi - Department of Chemistry, University of California, Davis

Collections: Chemistry