Carbohydrate materials have become increasingly utilized in
transplantation and cell/tissue engineering within the past year.
This has been well documented in recent applications of
immobilized or soluble -galactosyl epitopes
(i.e. oligosaccharides with a terminal Gal13Gal sequence)
in preventing hyperacute rejection in pig-to-primate
xenotransplantation. In addition, -galactosyl polymers have
been shown to exhibit much greater activity (up to 104 times)
than -galactosyl monomers in inhibiting the binding of anti-
galactosyl antibodies to pig kidney epithelial cells and assisting
in the prevention of cytotoxicity in human serum.
Department of Chemistry, Wayne State University, Detroit, MI 48202,
Correspondence: Peng George Wang
Current Opinion in Chemical Biology 1999, 3:650658
1367-5931/99/$ -- see front matter © 1999 Elsevier Science Ltd.
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