Home

About

Advanced Search

Browse by Discipline

Scientific Societies

E-print Alerts

Add E-prints

E-print Network
FAQHELPSITE MAPCONTACT US


  Advanced Search  

 
The Center for Control, Dynamical Systems, and Computation University of California at Santa Barbara
 

Summary: The Center for Control, Dynamical Systems, and Computation
University of California at Santa Barbara
Winter 2008 Systems Biology
Seminar Series Presents
Using Control Theory to Study Biological Systems:
Perfect Adaptation in the Osmo-Response Signaling
Network of S. Cerevisiae
Carlos Gómez-Uribe
Massachusetts Institute of Technology
Friday, January 18, 2008 3:00-4:00pm Harold Frank Hall 1104
Abstract:
Yeast cells must carefully regulate their internal osmolyte concentrations, partic-
ularly in response to osmotic changes in their environment. The protein Hog1,
embedded in a well-characterized signaling network, is an important mediator of
this osmo-response. We measure Hog1 dynamics in response to hyper osmotic
shocks at the single cell level, and find that the steady-state level of Hog1 activity
in response to a step input is identical to its pre-stimulus level, a behavior termed
perfect adaptation. We use simple control theory ideas to guide our experiments
and find the biological process responsible for the perfect adaptation: osmolyte
production providing integral feedback. Furthermore, we show that while the gene

  

Source: Akhmedov, Azer - Department of Mathematics, University of California at Santa Barbara

 

Collections: Mathematics