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R E V I E W S NATURE REVIEWS | GENETICS VOLUME 5 | OCTOBER 2004 | 773
 

Summary: R E V I E W S
NATURE REVIEWS | GENETICS VOLUME 5 | OCTOBER 2004 | 773
5 splice site (5ss) signal that only supported constitu-
tive splicing accumulated mutations. The effect of the
mutations was to sub-optimize that site, allowing it to
be used in alternative splicing as well.The 5ss that only
supports constitutive splicing is found in lower eukary-
otic organisms (mostly unicellular organisms such as
yeast),whereas the one that supports alternative splicing
is found in higher eukaryotic cells (mostly of multicellu-
lar organisms). So, might there be a link between the
higher orders of complexity in higher organisms and
alternative splicing?
An evolutionary overview
The vast majority of introns in eukaryotic gene families
are unlikely to have been derived from the most recent
common ancestral genes,but were gained subsequently,
leading to the formation of multi-intron genes5,6
. The
appearance of multi-intron genes probably predated

  

Source: Ast, Gil - Department of Molecular Genetics and Biochemistry, Tel Aviv University

 

Collections: Biology and Medicine